De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma in situ
Nabrinsky E, Masood F, AbdulMujeeb S, Asado N, Almanaseer I, Galvez A. De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ. Leuk Res Rep. 2021 Feb 9;15:100237. doi: 10.1016/j.lrr.2021.100237. PMID: 33665080; PMCID: PMC7902915
Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association between BRCA carriers and AML. We report a case of a young female BRCA carrier who develops de novo AML without prior chemoradiation treatment, and examine if there is a link between BRCA and developing leukemia.