De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma in situ

Authors

Edward Nabrinsky, Advocate Aurora HealthFollow
Faisal Masood, Advocate Aurora HealthFollow
Sufyan Abdulmujeeb, Advocate Aurora HealthFollow
Nahren Asado, Advocate Aurora HealthFollow
Imad Almanaseer, Advocate Aurora HealthFollow
Angel Galvez, Advocate Aurora HealthFollow

Recommended Citation

Nabrinsky E, Masood F, AbdulMujeeb S, Asado N, Almanaseer I, Galvez A. De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ. Leuk Res Rep. 2021 Feb 9;15:100237. doi: 10.1016/j.lrr.2021.100237. PMID: 33665080; PMCID: PMC7902915

Affiliations

Department of Internal Medicine, Advocate Lutheran General Hospital

Department of Pathology, Advocate Lutheran General Hospital

Department of Hematology and Oncology, Advocate Lutheran General Hospital

Abstract

Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association between BRCA carriers and AML. We report a case of a young female BRCA carrier who develops de novo AML without prior chemoradiation treatment, and examine if there is a link between BRCA and developing leukemia.

Document Type

Article

PubMed ID

33665080