Clinical implications of sodium zirconium cyclosilicate therapy in patients with systolic heart failure and hyperkalemia


Advocate Christ Medical Center


BACKGROUND: Sodium zirconium cyclosilicate (SZC), a newly introduced specific potassium binder, is introduced to treat hyperkalemia. However, the implications of SZC in up-titrating renin-angiotensin-aldosterone system inhibitors in patients with systolic heart failure remain unknown. METHODS AND RESULTS: Patients with heart failure with left ventricular ejection fraction <50% and hyperkalemia who had completed 3-month SZC therapy were retrospectively included. Serum potassium levels, the dose of renin-angiotensin-aldosterone system inhibitors, and echocardiographic parameters during the 3-month SZC therapy as compared with the pretreatment 3-month period were investigated. A total of 24 patients (median 77 years old, 71% men, median left ventricular ejection fraction 41%) received a 3-month SZC therapy without any associated adverse events including hypokalemia. Compared with the pretreatment period, serum potassium levels decreased, doses of renin-angiotensin-aldosterone system inhibitors increased, and the left ventricular ejection fraction and plasma B-type natriuretic peptide levels improved following the 3-month SZC therapy ( < 0.05 for all). CONCLUSIONS: SZC may be a promising therapeutic option to improve hyperkalemia, indirectly allowing up-titration of renin-angiotensin-aldosterone system inhibitors and facilitating reverse remodeling in patients with heart failure with a left ventricular ejection fraction <50% and hyperkalemia.

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