A retrospective analysis of gabapentinoid and opioids to opioid monotherapy for pain relief in patients with chronic neck and low back pain
Knezevic NN, Aijaz T, Camacho-Ortega A, Candido KD. A Retrospective Analysis of Gabapentinoid and Opioids to Opioid Monotherapy for Pain Relief in Patients with Chronic Neck and Low Back Pain. Pain Med. 2021;22(8):1760-1766. doi:10.1093/pm/pnab006
OBJECTIVE: We compared the reduction in pain and opioid consumption in patients with chronic spinal pain on concomitant gabapentinoids and opioids with patients using opioids only.
DESIGN: This was a retrospective chart review of patients with chronic neck or low back pain who were on opioids with at least 24-month follow-up.
SETTING: Single-center pain clinic in an urban setting.
SUBJECTS: 167 patients with chronic spinal pain lasting at least 6 months.
METHOD: Patients on gabapentin or pregabalin were included in the gabapentinoid group, while the other patients were included in the non-gabapentinoid group. Primary outcome was assessment of pain scores measured via a numeric rating scale (NRS), and secondary outcomes were response to the treatment (>2 point reduction on NRS) and daily opioid use measured in morphine milliequivalents.
RESULTS: Pain scores were reduced in the first 6 months and plateaued after that in both groups. At the end of 24 months, the average pain score was 6.71 in the gabapentinoid group, while the average pain score was 7.18 in the non-gabapentinoid group. There was no statistical significance between the groups (p = 0.28). There was no difference in response to treatment in gabapentinoid group (33.3%) when compared to non-gabapentinoid group (32.7%). We also failed to find any significant difference in daily opioid usage between the two groups.Conclusion: Gabapentinoids may not lead to reduction in pain or opioid consumption in patients with chronic spinal pain. A careful approach must be adopted while prescribing gabapentinoids in the chronic spinal pain patient population.