An unusual genetic observation in a case of short-coupled PVC-triggered ventricular fibrillation

Authors

Sunandan Sikdar, Narayana Multispeciality Hospital, Kolkata, India.
Debabrata Bera, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India.
Kapil Kumawat, Narayana Institute of Cardiac Sciences, Bangalore, India.
Arshad Jahangir, Advocate Aurora HealthFollow
Praloy Chakraborty, Department of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada.Follow

Recommended Citation

Sikdar S, Bera D, Kumawat K, Jahangir A, Chakraborty P. An Unusual Genetic Observation in a Case of Short-Coupled PVC-Triggered Ventricular Fibrillation. JACC Case Rep. 2022;4(23):101651. Published 2022 Nov 7. doi:10.1016/j.jaccas.2022.09.018

Affiliations

Aurora Center for Advanced Atrial Fibrillation Therapies, Aurora Cardiovascular & Thoracic Services, Aurora St. Luke's Medical Center

Abstract

Ventricular fibrillation induced by short-coupled premature ventricular complex is an uncommon cause of cardiac arrest in young individuals with no structural heart disease. The genetic substrate of this condition is heterogeneous and remains incompletely defined. We describe a case of short-coupled premature ventricular complex-triggered ventricular fibrillation with a likely pathogenic variant in the titin (TTN) gene. (Level of Difficulty: Advanced.).

Type

Article

PubMed ID

36507288