An unusual genetic observation in a case of short-coupled PVC-triggered ventricular fibrillation
Sikdar S, Bera D, Kumawat K, Jahangir A, Chakraborty P. An Unusual Genetic Observation in a Case of Short-Coupled PVC-Triggered Ventricular Fibrillation. JACC Case Rep. 2022;4(23):101651. Published 2022 Nov 7. doi:10.1016/j.jaccas.2022.09.018
Ventricular fibrillation induced by short-coupled premature ventricular complex is an uncommon cause of cardiac arrest in young individuals with no structural heart disease. The genetic substrate of this condition is heterogeneous and remains incompletely defined. We describe a case of short-coupled premature ventricular complex-triggered ventricular fibrillation with a likely pathogenic variant in the titin (TTN) gene. (Level of Difficulty: Advanced.).
Aurora Center for Advanced Atrial Fibrillation Therapies, Aurora Cardiovascular & Thoracic Services, Aurora St. Luke's Medical Center