Center for Integrative Research on Cardiovascular Aging, Aurora Research Institute, Aurora Cardiovascular Services, Aurora Health Care

Presentation Notes

Poster presented at: Aurora Scientific Day; May 25, 2016; Milwaukee, WI.


Conclusions: Simvastatin prevents the pro-fibrotic cytokine, TGF-B1 induced differentiation of fibroblasts to myofibroblasts by SMAD2/3 dephosphorylation via phosphatases: PPM1A and PP2A.

The involvement of PPM1A and PP2A in the anti-fibrotic effect of simvastatin reveals novel signaling mediators that may be selectively targeted for prevention of myocardial injury-induced ventricular fibrosis and heart failure.

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