Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19
Ruge M, Gomez JMD, du Fay de Lavallaz J, Hlepas A, Rahman A, Patel P, Hoster C, Lavani P, Nair GG, Jahan N, Alan Simmons J, Rao AK, Cotts W, Williams K, Volgman AS, Marinescu K, Suboc T. Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19. Am Heart J Plus. 2021 Apr;4:100022. doi: 10.1016/j.ahjo.2021.100022. Epub 2021 Jun 15. PMID: 34151308; PMCID: PMC8204812
Background: In the coronavirus disease 2019 (COVID-19) global pandemic, patients with cardiovascular disease represent a vulnerable population with higher risk for contracting COVID-19 and worse prognosis with higher case fatality rates. However, the relationship between COVID-19 and heart failure (HF) is unclear, specifically whether HF is an independent risk factor for severe infection or if other accompanying comorbidities are responsible for the increased risk.
Methods: This is a retrospective analysis of 1331 adult patients diagnosed with COVID-19 infection between March and June 2020 admitted at Rush University System for Health (RUSH) in metropolitan Chicago, Illinois, USA. Patients with history of HF were identified by International Classification of Disease, Tenth Revision (ICD-10) code assignments extracted from the electronic medical record. Propensity score matching was utilized to control for the numerous confounders, and univariable logistic regression was performed to assess the relationship between HF and 60-day morbidity and mortality outcomes.
Results: The propensity score matched cohort consisted of 188 patients in both the HF and no HF groups. HF patients did not have lower 60-day mortality (OR 0.81;
Conclusions: This study highlights the complex network of confounders present between HF and COVID-19. When balanced for these numerous factors, those with HF appear to be at no higher risk of 60-day mortality from COVID-19 but are at increased risk for morbidity.