Title

Clinical outcomes of patients treated for candida auris infections in a multisite health system, Illinois, USA

Affiliations

Advocate Lutheran General Hospital

Advocate South Suburban Hospital

Advocate Christ Medical Center

Advocate Illinois Masonic Medical Center

Advocate Condell Medical Center

Abstract

Candida auris is an emerging fungal pathogen that is typically resistant to fluconazole and is known to cause healthcare-associated outbreaks. We retrospectively reviewed 28 patients who had >1 positive culture for C. auris within a multisite health system in Illinois, USA, during May 2018-April 2019. Twelve of these patients were treated as inpatients for C. auris infections; 10 (83%) met criteria for clinical success, defined as absence of all-cause mortality, C. auris recurrence, and infection-related readmission at 30 days from the first positive culture. The other 2 patients (17%) died within 30 days. Most patients (92%) were empirically treated with micafungin. Four (14%) of 28 total isolates were resistant to fluconazole, 1 (3.6%) was resistant to amphotericin B, and 1 (3.6%) was resistant to echinocandins. Our findings describe low rates of antifungal resistance and favorable clinical outcomes for most C. auris patients.

Document Type

Article

PubMed ID

32310077

DOI

10.3201/eid2605.191588

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