Title

Glucocorticoid receptor polymorphisms in children undergoing congenital heart surgery with cardiopulmonary bypass

Affiliations

Division of Cardiology, Department of Pediatrics, Advocate Children's Hospital

Abstract

We conducted a candidate gene association study to test the hypothesis that different gene polymorphisms will be associated with corticosteroid responsiveness and study outcomes among children undergoing congenital heart surgery. This is a prospective observational cohort study at a large, tertiary pediatric cardiac center on children undergoing corrective or palliative congenital heart surgery. A total of 83 children were enrolled. DNA was isolated for three polymorphisms of interest namely N363 (rs56149945) and 9β (rs6198) associated with increased sensitivity to corticosteroids and

Document Type

Article

PubMed ID

33133738

DOI

10.1055/s-0040-1709658

Link to Full Text

 

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