Single-syringe administration of diluted adenosine.
McDowell, Marc; Mokszycki, Robert; Greenberg, Allyson; Hormese, Mary; Lomotan, Nadine; and Lyons, Neal, "Single-syringe administration of diluted adenosine." (2020). Pharmacy and Pharmacology. 51.
Supraventricular tachycardia (SVT) is a potentially life‐threatening disease state which accounts for 50,000 emergency department (ED) visits annually. SVT encompasses a variety of rhythm disturbances including atrial fibrillation, atrial flutter, sinus tachycardia, atrioventricular nodal reentrant tachycardia, and atrioventricular reciprocating tachycardia. The American Heart Association 2015 guidelines for Adult Advanced Cardiac Life Support recommends adenosine in nonhypotensive patients in regular narrow‐complex SVT. Adenosine is an endogenous purine nucleoside that blocks atrioventricular nodal conduction via the A1 receptors in the cardiac tissue. These in turn act on Gi‐cAMP to stimulate potassium channels yielding hyperpolarization of cardiac myocytes thus returning the heart to a normal sinus rhythm (NSR