Which medications work best for menorrhagia?
Lale A, Halajian E, Guthmann R, Nashelsky J. Which medications work best for menorrhagia? J Fam Pract. 2020 Sep;69(7):E11-E13. PMID: 32936851
Evidence summary A 2015 Cochrane review of the LNG-IUS for menorrhagia included 1 placebo-controlled RCT; most of the remaining 21 RCTs compared the LNG-IUS to invasive procedures such as endometrial ablation or hysterectomy.1 The placebo-controlled trial compared the LNG-IUS with placebo in 40 women on anticoagulation therapy and found a mean beneficial difference of 100 mL (95% confidence interval [CI], –116 to –83) using a subjective pictorial blood assessment chart.