Title

Association of dairy consumption with metabolic syndrome, hypertension and diabetes in 147 812 individuals from 21 countries

Authors

Balaji Bhavadharini, Hamilton Health Sciences
Mahshid Dehghan, Hamilton Health Sciences
Andrew Mente, Hamilton Health Sciences
Sumathy Rangarajan, Hamilton Health Sciences
Patrick Sheridan, Hamilton Health Sciences
Viswanathan Mohan, Madras Diabetes Research Foundation
Romaina Iqbal, The Aga Khan University
Rajeev Gupta, Eternal Heart Care Centre and Research Institute
Scott Lear, Simon Fraser University
Edelweiss Wentzel-Viljoen, North-West University
Alvaro Avezum, Instituto Dante Pazzanese de Cardiologia
Patricio Lopez-Jaramillo, Universidad de Santander
Prem Mony, St. John's Medical College
Ravi Prasad Varma, Achutha Menon Centre for Health Science Studies
Rajesh Kumar, Postgraduate Institute of Medical Education & Research, Chandigarh
Jephat Chifamba, University of Zimbabwe
Khalid F. Alhabib, King Saud University
Noushin Mohammadifard, Isfahan University of Medical Sciences
Aytekin Oguz, T.C. Saglik Bakanligi Istanbul Goztepe Egitim ve Arastirma Hastanesi
Fernando Lanas, Universidad de la Frontera
Dorota Rozanska, Wroclaw Medical University
Kristina Bengtsson Bostrom, Göteborgs Universitet
Khalid Yusoff, Universiti Teknologi MARA
Lungiswa P. Tsolkile, University of the Western Cape
Antonio Dans, University of the Philippines System
Afzalhussein Yusufali, Dubai Health Authority
Andres Orlandini, Estudios Clinicos Latinoamerica
Paul Poirier, Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Rasha Khatib, Advocate Aurora Health
Bo Hu, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
Li Wei, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Lu Yin, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

Objective: Our aims were to assess the association of dairy intake with prevalence of metabolic syndrome (MetS) (cross-sectionally) and with incident hypertension and incident diabetes (prospectively) in a large multinational cohort study.

Methods: The Prospective Urban Rural Epidemiology (PURE) study is a prospective epidemiological study of individuals aged 35 and 70 years from 21 countries on five continents, with a median follow-up of 9.1 years. In the cross-sectional analyses, we assessed the association of dairy intake with prevalent MetS and its components among individuals with information on the five MetS components (n=112 922). For the prospective analyses, we examined the association of dairy with incident hypertension (in 57 547 individuals free of hypertension) and diabetes (in 131 481 individuals free of diabetes).

Results: In cross-sectional analysis, higher intake of total dairy (at least two servings/day compared with zero intake; OR 0.76, 95% CI 0.71 to 0.80, p-trend<0.0001) was associated with a lower prevalence of MetS after multivariable adjustment. Higher intakes of whole fat dairy consumed alone (OR 0.72, 95% CI 0.66 to 0.78, p-trend<0.0001), or consumed jointly with low fat dairy (OR 0.89, 95% CI 0.80 to 0.98, p-trend=0.0005), were associated with a lower MetS prevalence. Low fat dairy consumed alone was not associated with MetS (OR 1.03, 95% CI 0.77 to 1.38, p-trend=0.13). In prospective analysis, 13 640 people with incident hypertension and 5351 people with incident diabetes were recorded. Higher intake of total dairy (at least two servings/day vs zero serving/day) was associated with a lower incidence of hypertension (HR 0.89, 95% CI 0.82 to 0.97, p-trend=0.02) and diabetes (HR 0.88, 95% CI 0.76 to 1.02, p-trend=0.01). Directionally similar associations were found for whole fat dairy versus each outcome.

Conclusions: Higher intake of whole fat (but not low fat) dairy was associated with a lower prevalence of MetS and most of its component factors, and with a lower incidence of hypertension and diabetes. Our findings should be evaluated in large randomized trials of the effects of whole fat dairy on the risks of MetS, hypertension, and diabetes.

Document Type

Article

PubMed ID

32423962

DOI

10.1136/bmjdrc-2019-000826

Link to Full Text

 

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