Applications, limitations, and considerations of clinical trials in a dish

Authors

Amatullah Mir, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Angie Zhu, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Rico Lau, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Nicolás Barr, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Zyva Sheikh, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Diana Acuna, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Anuhya Dayal, Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
Narutoshi Hibino, Advocate Health - MidwestFollow

Recommended Citation

Mir A, Zhu A, Lau R, et al. Applications, Limitations, and Considerations of Clinical Trials in a Dish. Bioengineering (Basel). 2024;11(11):1096. Published 2024 Oct 30. doi:10.3390/bioengineering11111096

Affiliations

Advocate Children's Hospital, Oak Lawn

Abstract

Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation.

Type

Article

PubMed ID

39593756