Steroid-induced Takotsubo cardiomyopathy in a patient with immune thrombocytopenic purpura

Authors

• Qutaiba Qafisheh, Department of Medicine University of Toledo Toledo Ohio USA.
• Roaa Aljunaidi, Faculty of Medicine and Health Sciences Palestine Polytechnic University Hebron Palestine.
• Abdalhakim Shubietah, Advocate Health - MidwestFollow
• Mohammed AbuBaha, Department of Medicine An-Najah National University Nablus Palestine.
• Hossam Salameh, Department of Medicine An-Najah National University Nablus Palestine.
• Muath Baniowda, Department of Medicine University of Missouri-Kansas City Kansas City Missouri USA.
• Mohanad Qwaider, Department of Medicine University of Toledo Toledo Ohio USA.
• Mohammad Alqadi, Department of Medicine University of Toledo Toledo Ohio USA.
• Imad Hariri, ProMedica Physician Group - Cardiology Toledo Ohio USA.

Recommended Citation

Qafisheh Q, Aljunaidi R, Shubietah A, et al. Steroid-Induced Takotsubo Cardiomyopathy in a Patient With Immune Thrombocytopenic Purpura. Clin Case Rep. 2025;13(10):e71047. Published 2025 Oct 3. doi:10.1002/ccr3.71047

Affiliations

Advocate Illinois Masonic Medical Center

Abstract

This case report highlights a temporal relationship between dexamethasone administration and the onset of Takotsubo cardiomyopathy, underscoring the importance of recognizing pharmacologic agents as potential non-traditional triggers, particularly in patients with underlying cardiovascular disease and no identifiable emotional or physical stressors. Diagnosis favored a dexamethasone-triggered Takotsubo phenotype based on non-obstructive coronaries, regional wall-motion abnormalities extending beyond a single arterial territory, absence of alternate stressors, and biologic plausibility of steroid-mediated catecholaminergic upregulation.

Type

Article

PubMed ID

41909096