Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARS-CoV-2: A retrospective study

Maryam Salah Al-Mazedi, Dept. of Medical Laboratory Technology, Public Authority for Applied Education and Training, Kuwait.
Rajesh Rajan, Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.
Mohammed Al-Jarallah, Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.
Raja Dashti, Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.Follow
Ahmad Al Saber, Department of Mathematics and Statistics, University of Strathclyde, Glasgow, G1 1XH, UK.
Jiazhu Pan, Department of Mathematics and Statistics, University of Strathclyde, Glasgow, G1 1XH, UK.
Kobalava D. Zhanna, Department of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named After V.S. Moiseev, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation.
Hassan Abdelnaby, Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Department of Medicine, Division of Gastroenterology, Al Sabah Hospital, Kuwait.Follow
Wael Aboelhassan, Department of Medicine, Division of Gastroenterology, Jaber Al Ahmed Hospital, South Surra, Kuwait.
Farah Almutairi, Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
Naser Alotaibi, Department of Medicine, Al Adan Hospital, Hadiya, Kuwait.
Mohammad Al Saleh, Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
Noor AlNasrallah, Department of Medicine, Al Adan Hospital, Hadiya, Kuwait.
Bader Al-Bader, Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
Haya Malhas, Department of Emergency Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.
Maryam Ramadhan, Department of Obstetrics and Gynaecology, Maternity Hospital, Shuwaikh Medical Area, Kuwait.
Peter A. Brady, Advocate Aurora HealthFollow
Ibrahim Al-Zakwani, Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman & Gulf Health Research, Muscat, Oman.Follow
Parul Setiya, Department of Agrometeorology, College of Agriculture, G.B.Pant University of Agriculture & Technology, Pantnagar, Uttarakhand, India.
Mohammed Abdullah, Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait.
Moudhi Alroomi, Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait.
Gary Tse, Cardiovascular Analytics Group, Hong Kong, China; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China.

Affiliations

Illinois Masonic Medical Center

Abstract

The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI): 15.5-40.0; p < 0.001), male sex (OR, 3.5; 95% CI: 2.0-5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94-0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan-Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients.

Type

Article

PubMed ID

36212733

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