Change in caregiver health-related quality of life from before to early after surgery: SUSTAIN-IT study

Sarah Chuzi, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).
Jane E. Wilcox, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).
Andrew Kao, St. Luke's Medical Center, Kansas City, MO (A.K.).
John A. Spertus, University of Missouri-Kansas City (J.A.S.).
Eileen Hsich, Cleveland Clinic, OH (E.H.).
Mary Amanda Dew, University of Pittsburgh, PA (M.A.D.).
Clyde W. Yancy, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).
Duc T. Pham, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).
Justin Hartupee, Washington University, St. Louis, MO (J.H.).
Michael Petty, University of Minnesota Medical Center, Minneapolis (M.P.).
William Cotts, Advocate Aurora HealthFollow
Salpy V. Pamboukian, University of Alabama-Birmingham (S.V.P., J.K.K.).
Francis D. Pagani, University of Michigan, Ann Arbor (F.D.P.).
Brent Lampert, Ohio State University, Columbus (B.L.).
Maryl Johnson, University of Wisconsin, Madison (M.J., M.M.).
Margaret Murray, University of Wisconsin, Madison (M.J., M.M.).
Koji Takeda, Columbia University, New York (K.T., M.Y.).
Melana Yuzefpolskaya, Columbia University, New York (K.T., M.Y.).
Scott Silvestry, Florida Hospital, Orlando (S.S.).
James K. Kirklin, University of Alabama-Birmingham (S.V.P., J.K.K.).
Tingqing Wu, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).
Adin-Cristian Andrei, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).Follow
Abigail Baldridge, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).Follow
Kathleen L. Grady, Northwestern University, Chicago, IL (S.C., J.E.W., C.W.Y., D.T.P., T.W., A.-C.A., A.B., K.L.G.).

Affiliations

Advocate Christ Medical Center

Abstract

Background: Information about health-related quality of life (HRQOL) among caregivers of older patients with heart failure who receive heart transplantation (HT) and mechanical circulatory support (MCS) is sparse. We describe differences and factors associated with change in HRQOL before and early post-surgery among caregivers of older heart failure patients who underwent 3 surgical therapies: HT with pretransplant MCS (HT MCS), HT without pretransplant MCS (HT non-MCS), and long-term MCS.

Methods: Caregivers of older patients (60-80 years) from 13 US sites completed the EQ-5D-3 L visual analog scale (0 [worst]-100 [best] imaginable health state) and dimensions before and 3 and 6 months post-surgery. Analyses included linear regression, t tests, and nonparametric tests.

Results: Among 227 caregivers (HT MCS=54, HT non-MCS=76, long-term MCS=97; median age 62.7 years, 30% male, 84% White, 83% spouse/partner), EQ-5D visual analog scale scores were high before (84.8±14.1) and at 3 (84.7±13.0) and 6 (83.9±14.7) months post-surgery, without significant differences among groups or changes over time. Patient pulmonary hypertension presurgery (β=-13.72 [95% CI, -21.07 to -6.36]; PP=0.035) were associated with the largest decrements in caregiver HRQOL; patient marital/partner status (β=6.21 [95% CI, 1.34-11.08]; P=0.013) and presurgery coronary disease (β=8.98 [95% CI, 4.07-13.89]; P

Conclusions: Caregivers of older patients undergoing heart failure surgeries reported overall high HRQOL before and early post-surgery. Understanding factors associated with caregiver HRQOL may inform decision-making and support needs.

Registration:NCT02568930.

Type

Article

PubMed ID

37345518

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