High-intensity statin therapy and associated rhabdomyolysis in chronic liver disease: A case report and review of literature

Authors

Mohan Chandra Gudiwada, Advocate Aurora HealthFollow
Vinuthna Gaddam, Advocate Aurora HealthFollow
Maheen Rahman, Advocate Aurora HealthFollow
Jaswanth R. Jasti, Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.
Paritaben Bhalodia, Advocate Aurora HealthFollow
Sahas Reddy Jitta, Internal Medicine, Osmania Medical College, Hyderabad, IND.

Recommended Citation

Gudiwada MCVB, Gaddam V, Rahman M, Jasti JR, Bhalodia P, Jitta SR. High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature. Cureus. 2023;15(5):e39150. Published 2023 May 17. doi:10.7759/cureus.39150

Affiliations

Advocate Illinois Masonic Medical Center

Abstract

Current literature suggests an increased incidence of rhabdomyolysis in patients with chronic liver disease (CLD) compared to the general population. We present a case of a 60-year-old female with a history of non-alcoholic fatty liver disease and cirrhosis who developed rhabdomyolysis and acute kidney injury after starting high-intensity atorvastatin therapy. This case highlights the potential risks associated with high-intensity statin therapy in patients with CLD, particularly those with advanced liver dysfunction, emphasizing the need for cautious prescribing and thorough risk-benefit assessment in this vulnerable patient population.

Type

Article

PubMed ID

37378115