Principles of evidence-based medicine

Authors

Nebojsa Nick Knezevic, Advocate Health - MidwestFollow
Laxmaiah Manchikanti
Joshua A. Hirsch

Recommended Citation

Knezevic NN, Manchikanti L, Hirsch JA. Principles of Evidence-Based Medicine. In: Navani A, Atluri S, Sanapati M, eds. Essentials of Regenerative Medicine in Interventional Pain Management. Springer International Publishing; 2024:35-48.

Affiliations

Advocate Illinois Masonic Medical Center

Abstract

For medical purposes, evidence can be any data or information, whether it be strong or weak, obtained through experience, observational or experimental research. Evidence-based practice or medicine (EBM) evolved through a methodical, rational accumulation, analysis, and understanding of the evidentiary knowledge that can be applied in the clinical setting(s).

The main goal of interventional pain management research is to standardize techniques, improve effectiveness, and reduce the risk of adverse events. Randomized controlled trials (RCTs) are considered the gold standard of EBM. In RCTs, patients receive either an investigational or control treatment, in a randomized and blinded manner. The strongest sources of evidence constitute systematic reviews and meta-analyses. Systematic reviews minimize bias through a comprehensive search and selection of articles for review and provides assessment of the methodological quality of the studies.

Type

Book Chapter

Book Chapter/Book Details

In: Navani A, Atluri S, Sanapati M, eds. Essentials of Regenerative Medicine in Interventional Pain Management. Springer International Publishing; 2024.