Acute hypersensitivity pneumonitis associated with a high Ki-67 proliferative index

Authors

Edward Nabrinsky, Advocate Aurora HealthFollow
Amanda Kamar, Advocate Aurora HealthFollow
Dereen Mohammed Saeed
Michael Pins, Advocate Aurora HealthFollow
Arvey Stone, Advocate Aurora HealthFollow

Recommended Citation

Nabrinsky E, Kamar A, Mohammed Saeed D, Pins M, Stone A. Acute hypersensitivity pneumonitis associated with a high ki-67 proliferative index. Cureus. 2020;12(4):e7905.

Affiliations

Internal Medicine, Advocate Lutheran General Hospital

Pathology, Advocate Lutheran General Hospital

Pulmonary and Critical Care Medicine, Advocate Lutheran General Hospital

Abstract

Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. Mycobacterium avium complex (MAC) is the most common nontuberculous mycobacteria and is known to cause HSP with certain exposures. However, although certain histologic findings can be seen with HSP, a high ki-67 proliferation index is unusual and more commonly associated with malignancy. In this report, we discuss a case of MAC that had acute HSP associated with a high ki-67 proliferative index.

Document Type

Article

PubMed ID

32494520