Outcomes of surgical bioprosthetic aortic valve replacement in patients ≤65 and >65 years of age

Authors

Bob B. Kiaii, Department of Cardiac Surgery, London Health Sciences Centre, London, ON, Canada. Electronic address: bkiaii@ucdavis.edu.
Michael G. Moront, Cardiothoracic Surgery, ProMedica Toledo Hospital, Toledo, OH.
Himanshu J. Patel, Department of Cardiac Surgery, University of Michigan Hospitals, Ann Arbor, MI.
Marc Ruel, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Feryel Nawel Bensari, Cardiac Surgery Department, BICHAT Hôpital, Paris, France.
David C. Kress, Advocate Aurora HealthFollow
Fang Liu, Department of Biostatistics, Medtronic, Minneapolis, MN.
Robert J. Klautz, Cardiothoracic Surgery, Leiden University Medical Centre, Leiden, Netherlands.
Joseph F. Sabik, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH.

Recommended Citation

Kiaii BB, Moront MG, Patel HJ, et al. Outcomes of Surgical Bioprosthetic Aortic Valve Replacement in Patients Aged ≤65 and >65 Years. Ann Thorac Surg. 2023;116(3):483-490. doi:10.1016/j.athoracsur.2021.12.057

Affiliations

Aurora St. Luke's Medical Center

Abstract

BACKGROUND: Implantation of a bioprosthetic valve is a reasonable choice for patients aged >65 years. For middle-aged patients, there is less certainty about whether a mechanical or bioprosthetic valve is best. METHODS: The PERIcardial SurGical AOrtic Valve ReplacemeNt (PERIGON) Pivotal Trial is evaluating the safety and efficacy of the Avalus bioprosthesis. We evaluated clinical and echocardiographic outcomes through 5 years of follow-up, stratified by age ≤65 and >65 years. RESULTS: Two hundred seventy-one patients (24.2%) were ≤65 years old, and 847 (75.8%) were >65 years old. Most patients in both groups were male (217 [80.1%] vs 623 [73.6%], respectively; p=0.031). Younger patients had a lower STS risk of mortality (1.1±0.9% vs 2.2±1.4%, p65 years of age.

Document Type

Article

PubMed ID

35065064