Engendering reproductive health within oncologic survivorship trial, ECOG-ACRIN E1Q11

Authors

• Ashlesha A. Patel, Cook County Health/SHCC M/U NCORP, Chicago, IL.
• Ju-Whei Lee, Dana-Farber Cancer Institute-ECOG-ACRIN Biostatistics Center, Boston, MA.
• Howard A. Zaren, Nancy N and J C Lewis Cancer and Research Pavilion, Savanna, GA.
• Erika K. Radeke, Cook County Health/SHCC M/U NCORP, Chicago, IL.
• Thomas E. Lad, Cook County Health/SHCC M/U NCORP, Chicago, IL.
• Urjeet A. Patel, Cook County Health/SHCC M/U NCORP, Chicago, IL.
• Rachel E. Lerner, Park Nicollet Clinic, Saint Louis Park, MN.
• Jami A. Fukui, Hawaii M/U NCORP, Honolulu, HI.
• Della F. Makower, Montefiore Medical Center Jack D Weiler Hospital, New York, NY.
• Deimante M. Tamkus, Cook County Health/SHCC M/U NCORP, Chicago, IL.
• Kendrith M. Rowland, Carle Cancer Center, Urbana, IL.
• William M. Adler, Memorial Medical Center, Las Cruces, NM.
• Alyssa D. Throckmorton, Baptist Memorial Hospital and Cancer Center, Memphis, TN.
• Sharad A. Ghamande, Augusta University Medical Center, Augusta, GA.
• Jessica J. Croley, Saint Joseph Health System, Lexington, KY.
• Mary H. Hackney, Virginia Commonwealth University/Massey Cancer Center, Richmond, VA.
• Andrew W. Pippas, John B. Amos Cancer Center, Columbus, GA.
• Rubina Qamar, Advocate Health - Midwest
• Gary V. Burton, LSU Health Sciences Center at Shreveport, Shreveport, LA.
• David J. Andosky, Rocky Mountain Cancer Centers, Boulder, CO.
• Amanda R. Hathaway, Spartanburg Medical Center, Spartanburg, SC.
• Nanda K. Methuku, Southern Ohio Medical Center, Portsmouth, OH.
• William V. Tomlinson, AnMed Health Cancer Center, Anderson, SC.
• David Cella, Northwestern University Feinberg School of Medicine, Chicago, IL.
• Michael J. Fisch, M D Anderson Cancer Center, Houston, TX.
• Lynne I. Wagner, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Recommended Citation

Patel AA, Lee JW, Zaren HA, et al. Engendering Reproductive Health Within Oncologic Survivorship Trial, ECOG-ACRIN E1Q11. JCO Oncol Pract. Published online April 28, 2026. doi:10.1200/OP-25-00532

Affiliations

Aurora Cancer Care-Milwaukee West, Wauwatosa

Abstract

Purpose: For the 10% of women diagnosed with cancer within reproductive age, reproductive health is a critical component of oncologic survivorship. Variable attention to guidelines pertaining to oncocontraception and oncofertility results in cancer care discordant with a patient's reproductive health goals, negatively affecting quality of life. This study aimed to determine if the Engendering Reproductive Health within Oncologic Survivorship (EROS) multilevel intervention improves reproductive health goal-concordant management within 3 months of cancer diagnosis.

Patients and methods: EROS is a cluster randomized trial, with 17 US-based National Cancer Institute Community Oncology Research Program (NCORP) sites (including Minority/Underserved Sites) randomly assigned to receive either reproductive health intervention (RHI; eight sites) or standard of care (SC; nine sites). Eligible patients included patients age 15-55 years with a new cancer diagnosis. The multilevel intervention included reproductive health education and navigation components. The primary study outcome is reproductive health goal-concordant management.

Results: This ECOG-ACRIN trial enrolled 420 eligible patients from 17 NCORP sites, of which 379 had available data for the primary analysis (RHI n = 134; SC n = 245). Reproductive health goal-concordant management was achieved in 65.7% of women from RHI sites and 47.3% of women at SC sites (odds ratio [OR, RHI/SC], 2.07, 90% CI, 1.29 to 3.31). The intervention effect on reproductive health goal-concordant management was significant for women who had completed childbearing (OR [RHI/SC], 2.92 [90% CI, 1.65 to 5.17]; P = .002), whereas no such effect was observed among those who had not completed childbearing (OR [RHI/SC], 1.17 [90% CI, 0.72 to 1.89]; P = .60).

Conclusion: The EROS intervention demonstrated marked improvement of reproductive health goal-concordant care, especially among patients who had completed childbearing. The multilevel EROS intervention demonstrates promise to improve adherence to national cancer guidelines at the complex intersection of reproductive health and cancer survivorship.

Document Type

Article

PubMed ID

42048622