Virtual sustained tobacco treatment for patients with cancer: A randomized controlled trial (ECOG-ACRIN: EAQ171CD) within the National Cancer Institute Community Oncology research program

Authors

• Elyse R. Park, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• JoRean D. Sicks, Center for Biostatistics and Health Data Science, Brown University-ECOG-ACRIN Biostatistics Center, Providence, RI.
• Brett M. Goshe, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Ilana F. Gareen, Department of Epidemiology, Brown University School of Public Health, Providence, RI.
• Benjamin A. Herman, Center for Biostatistics and Health Data Science, Brown University-ECOG-ACRIN Biostatistics Center, Providence, RI.
• Alexander Taurone, Center for Biostatistics and Health Data Science, Brown University-ECOG-ACRIN Biostatistics Center, Providence, RI.
• Seth Bittig, Center for Biostatistics and Health Data Science, Brown University-ECOG-ACRIN Biostatistics Center, Providence, RI.
• Angela Wangari Walter, Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, Boston, MA.
• Susan Regan, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Rachel Rosen, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Natalie Durieux, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Autumn W. Rasmussen, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Douglas E. Levy, The Mongan Institute, Massachusetts General Hospital, Boston, MA.
• Gabriella Nicolosi, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Alona Muzikansky, Biostatistics Center, Massachusetts General Hospital, Boston, MA.
• Michael A. Thompson, Advocate Health - MidwestFollow
• Michelle Lui, Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.
• Laura Malloy, Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, Boston, MA.
• Irina Gonzalez, Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, Boston, MA.
• Lucy Finkelstein-Fox, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
• Nathan D. Munson, ThedaCare Regional Cancer Center, Appleton, WI.
• Molly M. Greenwade, CoxHealth South Hospital, Springfield, MO.
• David M. King, Metro Minnesota Community Oncology Res Consortium, Fridley, MN.
• Bharat Jenigiri, Physicians' Clinic of Iowa PC, Cedar Rapids, IA.
• Brian L. Burnette, Saint Vincent Hospital Cancer Center, Green Bay, WI.
• Alyssa D. Throckmorton, Baptist Memorial Hospital and Cancer Center, Memphis, TN.
• Martha S. Tingen, Augusta University Medical Center, Augusta, GA.
• Ruth C. Carlos, Department of Radiology, Columbia University, New York, NY.
• Lynne I. Wagner, University of North Carolina Chapel Hill, Chapel Hill, NC.
• et al

Recommended Citation

Park ER, Sicks JD, Goshe BM, et al. Virtual Sustained Tobacco Treatment for Patients With Cancer: A Randomized Controlled Trial (ECOG-ACRIN: EAQ171CD) Within the National Cancer Institute Community Oncology Research Program. J Clin Oncol. Published online July 13, 2026. doi:10.1200/JCO-25-02267

Abstract

Purpose: Persistent smoking among patients diagnosed with cancer is associated with adverse clinical outcomes, yet tobacco treatment has not been integrated into community oncology settings. We conducted a trial of a virtual sustained tobacco treatment intervention across community oncology settings nationwide.

Methods: This randomized controlled trial compared the effectiveness of sustained telehealth counseling plus medication (virtual sustained treatment [VST]) to referral to the National Cancer Institute (NCI) quitline (enhanced usual care [EUC]) in assisting patients recently diagnosed with cancer to quit smoking. The VST group received up to 11 synchronous telehealth sessions (four weekly, four biweekly, three monthly) of motivational counseling and up to 12 weeks of free nicotine replacement therapy (NRT).

Results: From August 2019 to December 2022, 306 English- and Spanish-speaking patients were randomly assigned from 37 NCI Community Oncology Research Program community sites. Participants were 70.9% female; 86.3% was White; the median age was 57 years; and 45.4% had non-smoking-related tumors. A total of 221 of 302 (73.2%) smoked within 30 minutes of waking. Six-month, 7-day point abstinence rates were 28.4% (42 of 148) in the VST group versus 14.7% (21 of 143) in the EUC group; there were no significant treatment moderators. A total of 80.8% (126 of 156) of VST participants engaged in counseling, and 85.7% (108 of 126) were dispensed NRT. Participants who completed >8 sessions versus <5 sessions were more likely to quit; P = .005. VST participants were almost four times more likely to report guideline-concordant smoking cessation medication use. Continuous abstinence and significant reduction rates at 6 months were higher in the VST group. The incremental cost per quit was $7,724 in US dollars.

Conclusion: Among recently diagnosed patients, sustained remotely delivered telehealth counseling and free NRT were well utilized and nearly doubled 6-month quit rates compared with EUC. Findings support the benefit of adopting sustained tobacco treatment within community oncology care settings nationwide.

Document Type

Article

PubMed ID

42441935