In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™

Authors

• Hamid Mansouri, Department of Mechanical, Industrial, and Manufacturing Engineering, University of Toledo, Toledo, OH, United States.
• Nedim Gulkaya, Galaxy Therapeutics Inc., Milpitas, CA, United States.
• Matthew J. Gounis, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
• Mohammad AlMajali, Mercy Health Neuroscience Institute, Neurology and Neurosurgery, Toledo, OH, United States.
• Amit Chaudhari, Mercy Health Neuroscience Institute, Neurology and Neurosurgery, Toledo, OH, United States.
• Darwin G. Ramirez Abreu, Mercy Health Neuroscience Institute, Neurology and Neurosurgery, Toledo, OH, United States.
• Syed F. Zaidi, Department of Neurology, University of Toledo, Toledo, OH, United States.
• Yazan K. Ashouri, Mercy Health Neuroscience Institute, Neurology and Neurosurgery, Toledo, OH, United States.
• Naoki Kaneko, Westwood Imaging Center & Interventional Radiology Clinic, Los Angeles, CA, United States.
• Brian T. Jankowitz, Hackensack Meridian Neuroscience Institute at JFK University Medical Center, Edison, NJ, United States.
• David J. Altschul, Montefiore Einstein Advanced Care Neurosurgery, Elmsford, NY, United States.
• Boris Pabon, Centro Comercial Cauca Centro, Universidad de Antioquia, Antioquia, Colombia.
• Pervinder Bhogal, Department of Interventional Neuroradiology, The Royal London Hospital, Barts NHS Trust, London, United Kingdom.
• Thomas J. Wolfe, Advocate Health - MidwestFollow
• Edgard L. Pereira, Neuro Endovascular Surgery, McLeod Medical Center, Florence, SC, United States.
• Aamir Badruddin, Powers Health Medical Group, Neurosurgery and Spinal Surgery, Munster, IN, United States.
• Laila Ibrahim, Galaxy Therapeutics Inc., Milpitas, CA, United States.
• Omid Amili, Department of Mechanical, Industrial, and Manufacturing Engineering, University of Toledo, Toledo, OH, United States.
• Osama O. Zaidat, Mercy Health Neuroscience Institute, Neurology and Neurosurgery, Toledo, OH, United States.

Recommended Citation

Mansouri H, Gulkaya N, Gounis MJ, et al. In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™. Front Neurol. 2026;17:1830746. Published 2026 Jun 19. doi:10.3389/fneur.2026.1830746

Affiliations

Aurora Neuroscience Innovation, Milwaukee

Abstract

Background: Intrasaccular devices such as SEAL™ and WEB™-SL are designed to disrupt aneurysmal flow. We present a new in vitro method for estimating neurointerventional devices' flow dynamics.

Methods: Particle image velocimetry (PIV) method was used in a patient-specific middle cerebral artery (MCA) wide-neck bifurcation aneurysm (WNBA) model to measure velocity, residence time (RT), and vorticity strength (VS). Tested devices included 3 each of SEAL-BASE (6 × 2 mm), SEAL-ARC (6 × 5 mm), and WEB-SL (6 × 4 mm).

Results: Twelve experiments were performed (3 unique devices per size and 3 controls); the mean RT was 0.042 ± 0.006 s (control) and increased with SEAL-BASE (0.387 ± 0.128), SEAL-ARC (0.33 ± 0.092), and WEB-SL (0.171 ± 0.034) (all p < 0.05 vs. control), and was longer in SEAL-BASE (p = 0.046) and SEAL-ARC (p = 0.041) than WEB-SL, with no difference between SEAL configurations (p = 0.30). The VS decreased from 66.48 ± 8.58 1/s (control) to 14.06 ± 2.80, 13.94 ± 2.53, and 27.60 ± 4.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively. The SEAL devices differed from WEB-SL (p = 0.007, 0.006) but not from each other (p = 0.52). Velocity magnitude dropped from 109.4 ± 15.5 mm/s (control) to 12.42 ± 3.8, 14.2 ± 3.5, and 25.34 ± 3.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively; greater reductions with SEAL-BASE (p = 0.006) and SEAL-ARC (p = 0.007) versus WEB-SL, with no difference between the two SEAL configurations (p = 0.29).

Conclusion: Both SEAL configurations achieved greater flow reduction compared to the WEB-SL of similar width in the same aneurysm model. Results highlight the unique utilization of the PIV method for the mechanistic decoupling of momentum transfer into the aneurysm sac resulting from intra-aneurysmal mesh structures and point toward their potential for further neurointerventional device optimization.

Document Type

Article

PubMed ID

42404115