Predicting the severity and Outcome of Persistent Pulmonary Hypertension of the Newborn Using New Echocardiography Parameters

Authors

Muhammad Umer Butt, Heart and Vascular Center, Metrohealth Medical Center, Cleveland, Ohio, USA.Follow
Ahmad Jabri, Heart and Vascular Center, Metrohealth Medical Center, Cleveland, Ohio, USA. Electronic address: jabri.ahmad1@gmail.com.
Hani Hamade, Department of Internal Medicine, Metrohealth Medical Center, Cleveland, Ohio, USA.
Ahmad Al Abdouh, Department of Medicine, St. Agnes Hospital, Baltimore, Maryland, USA.
Mohammad Mhanna, Department of Internal Medicine, University of Toledo, Toledo, Ohio, USA.
Faris Haddadin, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA.
Nour Hammad, Division of Nephrology, University Hospitals Cleveland Medical Centers, Cleveland, Ohio, USA.
Deaa Abu Jazar, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Ahmad J. Toumar, Department of Internal Medicine, Kent Hospital, Warwick, Rhode Island, USA.
Aisha Siraj, Heart and Vascular Center, Metrohealth Medical Center, Cleveland, Ohio, USA.
Kathir Balakumaran, Heart and Vascular Center, Metrohealth Medical Center, Cleveland, Ohio, USA.
Michel Ilbawi, Advocate Aurora HealthFollow

Recommended Citation

Butt MU, Jabri A, Hamade H, et al. Predicting the Severity and Outcome of Persistent Pulmonary Hypertension of the Newborn Using New Echocardiography Parameters. Curr Probl Cardiol. 2023;48(8):101181. doi:10.1016/j.cpcardiol.2022.101181

Affiliations

Pediatric Cardiac Team, Advocate Children's Heart Institute, Advocate Children's Hospital

Abstract

Objective: To examine echocardiographic (ECHO) parameters correlation with clinical severity indices, Alveolar- arterial gradient (A-a gradient), oxygenation index (OI) and clinical outcomes in newborns with persistent pulmonary hypertension of the newborn (PPHN).

Study design: Retrospective cohort study of 67 subjects, >35 weeks' gestation with the diagnosis of PPHN admitted to the University of Kentucky neonatal intensive care unit (NICU) between September 2014 and December 2016.

Results: High left ventricular end-systolic eccentricity index (EIs) correlates with the overall clinical severity of PPHN as it is associated with higher A-a gradient and OI (p=0.0003 and p1.38 provides cutoff value as an objective marker for the need for ECMO.

Conclusion: EIs can be used to assess clinical severity and outcomes and should be reported routinely. Further studies are warranted to confirm these results.

Document Type

Article

PubMed ID

35341801