Predicting the severity and Outcome of Persistent Pulmonary Hypertension of the Newborn Using New Echocardiography Parameters


Pediatric Cardiac Team, Advocate Children's Heart Institute, Advocate Children's Hospital


Objective: To examine echocardiographic (ECHO) parameters correlation with clinical severity indices, Alveolar- arterial gradient (A-a gradient), oxygenation index (OI) and clinical outcomes in newborns with persistent pulmonary hypertension of the newborn (PPHN).

Study design: Retrospective cohort study of 67 subjects, >35 weeks' gestation with the diagnosis of PPHN admitted to the University of Kentucky neonatal intensive care unit (NICU) between September 2014 and December 2016.

Results: High left ventricular end-systolic eccentricity index (EIs) correlates with the overall clinical severity of PPHN as it is associated with higher A-a gradient and OI (p=0.0003 and p<0.0001, respectively). Elevated EIs was also predictive for the use of inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO) (p=0.0004 and p<0.0001, respectively). EIs value of >1.38 provides cutoff value as an objective marker for the need for ECMO.

Conclusion: EIs can be used to assess clinical severity and outcomes and should be reported routinely. Further studies are warranted to confirm these results.

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