PATH 2 Purpose: Design of a comparative effectiveness study of prevention programs for adolescents at-risk for depression in the primary care setting

Tracy R. Gladstone, Wellesley Centers for Women, Wellesley College, Wellesley, MA 02481, USA.
Rebecca T. Feinstein, Department of Pediatrics, College of Medicine, University of Illinois, Chicago, IL 60612, USA. Electronic address: rfeinst@uic.edu.
Marian L. Fitzgibbon, Department of Pediatrics, College of Medicine, University of Illinois, Chicago, IL 60612, USA; Institute of Health Research and Policy, University of Illinois, Chicago, IL 60608, USA; University of Illinois Cancer Center, University of Illinois, Chicago, IL 60612, USA.
Linda Schiffer, Institute of Health Research and Policy, University of Illinois, Chicago, IL 60608, USA.
Michael L. Berbaum, Institute of Health Research and Policy, University of Illinois, Chicago, IL 60608, USA; University of Illinois Cancer Center, University of Illinois, Chicago, IL 60612, USA.
Cheryl Lefaiver, Advocate Aurora HealthFollow
Patrick Pössel, Department of Counseling and Human Development, University of Louisville, Louisville, KY 40292, USA.
Kathleen Diviak, Institute of Health Research and Policy, University of Illinois, Chicago, IL 60608, USA.
Tianxiu Wang, Institute of Health Research and Policy, University of Illinois, Chicago, IL 60608, USA.
Amanda K. Knepper, Department of Pediatrics, College of Medicine, University of Illinois, Chicago, IL 60612, USA.
Jennifer Sanchez-Flack, Department of Pediatrics, College of Medicine, University of Illinois, Chicago, IL 60612, USA; Institute of Health Research and Policy, University of Illinois, Chicago, IL 60608, USA.
Calvin Rusiewski, Department of Pediatrics, College of Medicine, University of Illinois, Chicago, IL 60612, USA.
Diane Potts, National Center for Rural Health Professions, College of Medicine, University of Illinois, Rockford, IL 61107, USA.
Katherine R. Buchholz, Wellesley Centers for Women, Wellesley College, Wellesley, MA 02481, USA.
Taylor L. Myers, Wellesley Centers for Women, Wellesley College, Wellesley, MA 02481, USA.
Benjamin W. Van Voorhees, Department of Pediatrics, College of Medicine, University of Illinois, Chicago, IL 60612, USA.

Affiliations

Advocate Aurora Research Institute

Abstract

The majority of mental, emotional, and behavioral (MEB) disorders have an initial onset before age 24, with 20% annual incidence, and with major depressive disorder (MDD) being the most common MEB. Health systems may be able to reduce costs by transitioning from the current treatment-focused model for MDD to a prevention model. However, evidence is needed for (1) the comparative effectiveness of a "scalable intervention" and (2) an implementation model for such a scalable intervention in the primary care setting. This paper describes a comparative effectiveness trial evaluating the efficacy of two evidence-based cognitive-behavioral prevention (CBP) programs: Teens Achieving Mastery over Stress (TEAMS), the "gold standard," group therapy model, and Competent Adulthood Transition with Cognitive Behavioral, Humanistic and Interpersonal Training (CATCH-IT), a scalable, self-directed, technology-based model. Eligible adolescents, age 13-19, are offered one of these two depression prevention programs across five health systems (30 clinics) in urban and suburban Chicago, IL, rural Western IL, and Louisville, KY. We are comprehensively evaluating patient-centered outcomes and stakeholder-valued moderators of effect versus baseline at two, six, 12, and 18-month assessment points. Using a hybrid clinical trial design that simultaneously examines the implementation process, the study is also assessing adolescents', parents', and providers' experiences (e.g., efficacy, time commitment, cultural acceptability) within each intervention approach.

Document Type

Article

PubMed ID

35436622

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