An 80-year-old woman with myelofibrosis and diffuse mosaic attenuation on chest computed tomography

Authors

Harpreet Singh, Department of Medicine, Division of Pulmonary and Critical Care, Medical College of, Wisconsin, Milwaukee, WI, USA.
Jonathan S. Kurman, Department of Medicine, Division of Pulmonary and Critical Care, Medical College of, Wisconsin, Milwaukee, WI, USA.
Chinmay T. Jani, Department of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA, USA.
Nagarjun Rao, Advocate Aurora HealthFollow
Bryan S. Benn, Department of Medicine, Division of Pulmonary and Critical Care, Medical College of, Wisconsin, Milwaukee, WI, USA.Follow

Recommended Citation

Singh H, Kurman JS, Jani CT, Rao N, Benn BS. An 80-year-old woman with myelofibrosis and diffuse mosaic attenuation on chest computed tomography. Respir Med Case Rep. 2022;38:101705. Published 2022 Jul 11. doi:10.1016/j.rmcr.2022.101705

Affiliations

Aurora Clinical Laboratories/Great Lakes Pathologists, Aurora West Allis Medical Center

Abstract

An 80-year-old woman with myelofibrosis sought evaluation for progressive dyspnea. Her past medical history included essential thrombocytosis, which transformed to myelofibrosis. Inspiratory computed tomography of chest showed diffuse mosaic attenuation with lymphadenopathy. Flexible bronchoscopy with lymph node and pulmonary parenchymal cryo biopsy revealed nodular deposits of extramedullary hematopoiesis in lung parenchyma and moderate to severe vascular medial and intimal thickening of pulmonary vasculature consistent with pulmonary parenchymal extramedullary hematopoiesis associated with pulmonary hypertension (a rare compensatory mechanism in myeloproliferative disorders). In this report, we explore the manifestations, pathogenesis, treatment, and prognosis of pulmonary extramedullary hematopoiesis reported in the literature.

Document Type

Article

PubMed ID

35864977