Obstructive and central sleep apnoea in a patient with medically intractable epilepsy

Authors

Katherine Schwartz, Advocate Aurora HealthFollow
Alejandra C. Lastra, Section of Pulmonary and Critical Care Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
Antoaneta J. Balabanov, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

Recommended Citation

Schwartz K, Lastra AC, Balabanov AJ. Obstructive and central sleep apnoea in a patient with medically intractable epilepsy. BMJ Case Rep. 2022;15(9):e245564. Published 2022 Sep 28. doi:10.1136/bcr-2021-245564

Abstract

A woman in her 30s with medically intractable epilepsy and Lennox-Gastaut Syndrome on multiple antiseizure medications and with a deep brain stimulator presented to the epilepsy monitoring unit with increased seizure frequency. She was noted to have periods of apparent apnoea time linked to bursts of epileptiform activity on continuous video EEG monitoring. Once the clinical seizures were controlled, she was discharged to the sleep laboratory. She was noted to have obstructive and central sleep apnoea, which improved with the use of positive airway pressure. Central sleep apnoeas were time linked to electrographic seizures. Ictal central apnoea can easily be overlooked and is likely more common than currently recognised in patients with epilepsy. Ictal central apnoea may be a biomarker for sudden unexpected death in epilepsy.

Document Type

Article

PubMed ID

36171011