The single-syringe versus the double-syringe techniques of adenosine administration for supraventricular tachycardia: A systematic review and meta-analysis

Authors

Isabele A. Miyawaki, Division of Medicine, Federal University of Paraná, 181 General Carneiro Street, Curitiba, PR, 80060-900, Brazil. isabeleayumi@ufpr.br.
Cintia Gomes, Division of Medicine, Federal University of Paraná, 181 General Carneiro Street, Curitiba, PR, 80060-900, Brazil.
Vittoria Caporal S Moreira, Division of Medicine, Israelita de Ciências da Saúde Albert Einstein University, São Paulo, São Paulo, Brazil.
Isabela R Marques, Division of Medicine, Universitat Internacional de Catalunya, Barcelona, Catalunya, Spain.
Isabela A F de Souza, Division of Medicine, Federal University of Paraná, 181 General Carneiro Street, Curitiba, PR, 80060-900, Brazil.
Caroliny H A Silva, Division of Medicine, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
José Eduardo Riceto Loyola Júnior, Division of Medicine, Federal University of Paraná, 181 General Carneiro Street, Curitiba, PR, 80060-900, Brazil.
Kangwook Huh, Internal Medicine Division, University of Connecticut, Farmington, CT, USA.
Marc McDowell, Advocate Aurora HealthFollow
Eduardo M. Padrao, Internal Medicine Division, University of Connecticut, Farmington, CT, USA.
Matthew B. Tichauer, Internal Medicine Division, University of Connecticut, Farmington, CT, USA.
Charles Michael Gibson, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Recommended Citation

Miyawaki IA, Gomes C, Caporal S Moreira V, et al. The Single-Syringe Versus the Double-Syringe Techniques of Adenosine Administration for Supraventricular Tachycardia: A Systematic Review and Meta-Analysis. Am J Cardiovasc Drugs. 2023;23(4):341-353. doi:10.1007/s40256-023-00581-w

Affiliations

Advocate Christ Medical Center

Abstract

Introduction:The intravenous double-syringe technique (DST) of adenosine administration is the first-line treatment for stable supraventricular tachycardia (SVT). Alternatively, the single-syringe technique (SST) was recently found to be potentially beneficial in several studies. This study aimed to perform a meta-analysis of the SST versus the DST of adenosine administration for the treatment of SVT.

Methods:We assessed EMBASE, PubMed, Cochrane, and ClinicalTrials.gov databases for randomized controlled trials (RCTs) and non-randomized studies of intervention (NRSIs) comparing the DST to the SST of adenosine administration in patients with SVT. Outcomes included termination rate, termination rate at first dose, total administered dose, adverse effects, and discharge rate.

Results:We included four studies (three RCTs and one NRSI) with a total of 178 patients, of whom 99 underwent the SST of adenosine administration. No significant difference was found between treatment groups regarding termination rate, termination rate restricted to RCTs, total administered dose, and discharge rate. Termination rate at first dose (odds ratio 2.87; confidence interval 1.11-7.41; p = 0.03; I2 = 0%) was significantly increased in patients who received the SST. Major adverse effects were observed in only one study.

Conclusions:The SST is probably as safe as the DST and at least as effective for SVT termination, SVT termination at first dose, and discharge rate from the emergency department. However, definitive superiority of one technique is not feasible given the limited sample size.

Document Type

Article

PubMed ID

37162718