Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery

Authors

Chung-Wei Lin, Department of Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Pei-Wen Lin, Division of Glaucoma, Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Li-Wen Chiu, Department of Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.Follow
Han-Tan Chai, Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.Follow
Chun-Tuan Chang, Department of Business Management, Institute of Healthcare Management, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.Follow
Michael Friedman, Advocate Aurora HealthFollow
Anna M. Salapatas, Advocate Aurora Health
Sara Rahavi-Ezabadi, Otorhinolaryngology Head and Neck Surgery Department, Otorhinolaryngology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Hsin-Ching Lin, College of Medicine, Chang Gung University, Taoyuan, Taiwan. hclin@adm.cgmh.org.tw.

Recommended Citation

Lin CW, Lin PW, Chiu LW, et al. Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery. J Otolaryngol Head Neck Surg. 2023;52(1):49. Published 2023 Jul 27. doi:10.1186/s40463-023-00653-6

Affiliations

Advocate Illinois Masonic Medical Center

Abstract

Background: Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR and PLR following obstructive sleep apnea (OSA) treatment were under studied and thus should be investigated. This study aimed to evaluate the changes of inflammatory biomarkers including NLR and PLR in severe OSA patients after surgical interventions of the upper airway, and their relationships with improvements in polysomnographic (PSG) parameters.

Methods: This retrospective cohort study included 563 consecutive severe OSA patients at a tertiary academic medical center who received OSA surgery, as well as underwent pre- and post-operative polysomnographic (PSG) examinations and blood tests. The changes of major PSG estimates, NLR, and PLR before and at least 3 months after OSA surgery were analyzed using paired t-tests with subgroup analyses. Pearson's correlations were performed to discover which PSG parameter contributed to the improvement of the values.

Results: After OSA surgery, the major PSG estimates, NLR and PLR dropped significantly in the overall population. In those with a higher preoperative NLR (pre-operative NLR≧3) and PLR (pre-operative PLR≧150), the mean (SD) difference of NLR (- 0.8 [1.6], 95% CI - 1.5 to - 0.2) and PLR (- 41.6 [40], 95% CI - 52.8 to - 30.5) were even more substantial. The changes of the "apnea, longest (r = 0.298, P = .037)" and "hypopnea, longest (r = 0.321, P = .026)" were found significantly related to the improvement of PLR.

Conclusion: NLR and PLR did significantly drop in severe OSA patients following OSA surgery, and this could be related to the alterations of sleep indices. The findings could possess clinical importance for severe OSA patients after OSA surgeries in reducing possible OSA-associated cardiovascular comorbidities.

Document Type

Article

PubMed ID

37501207