Description of a national, multi-center registry of patients with sickle cell disease and SARS-CoV-2 infection: Data from the Pediatric COVID-19 United States Registry
Authors
Aleksandra S. Dain, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Caroline Diorio, Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Brian T. Fisher, Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Jane S. Hankins, Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Pennsylvania, USA.
Char M. Witmer, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Mickael Boustany, Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Madeline Burton, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Pennsylvania, USA.
Jose Ferrolino, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Pennsylvania, USA.
Salma Sadaf, Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Hailey S. Ross, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Pennsylvania, USA.
Gabriela Maron, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Pennsylvania, USA.
Pediatric COVID-19 US Registry
Mary Murray, Advocate Health - MidwestFollow
Recommended Citation
Dain AS, Diorio C, Fisher BT, et al. Description of a national, multi-center registry of patients with sickle cell disease and SARS-CoV-2 infection: Data from the Pediatric COVID-19 United States Registry. Pediatr Blood Cancer. Published online March 12, 2024. doi:10.1002/pbc.30909
Abstract
Children with sickle cell disease (SCD) are at risk of complications from viral infections, including SARS-CoV-2. We present the clinical characteristics and outcomes of pediatric patients with SCD from the Pediatric COVID-19 United States Registry who developed acute COVID-19 due to SARS-CoV-2 infection (n = 259) or multisystem inflammatory syndrome in children (MIS-C; n = 4). Nearly half of hospitalized children with SCD and SARS-CoV-2 infection required supplemental oxygen, though children with SCD had fewer intensive care (ICU) admissions compared to the general pediatric and immunocompromised populations. All registry patients with both SCD and MIS-C required ICU admission. Children with SCD are at risk of severe disease with SARS-CoV-2 infection, highlighting the importance of vaccination in this vulnerable population.
Affiliations
Advocate Children's Hospital