Trends in genitourinary cancer mortality in the United States: Analysis of the CDC-WONDER database 1999-2020

Yahia Ghazwani, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Mohammad Alghafees, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Mahammed Khan Suheb, Advocate Health - MidwestFollow
Areez Shafqat, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Belal Nedal Sabbah, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Tarek Ziad Arabi, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Adhil Razak, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Ahmad Nedal Sabbah, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Marwan Alaswad, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Wael AlKattan, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Abderrahman Ouban, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Saleha Abdul Rab, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Kenan Abdulhamid Shawwaf, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Mohammad AlKhamees, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Ahmed Alasker, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Abdullah Al-Khayal, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Bader Alsaikhan, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Abdulmalik Addar, Department of Urology, McGill University, Montreal, QC, Canada.
Lama Aldosari, Department of Urology, King Fahad University Hospital, Khobar, Saudi Arabia.
Abdullah A. Al Qurashi, King Abdullah International Medical Research Centre, Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.
Ziyad Musalli, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia.

Affiliations

St. Luke's Aurora Hospital

Abstract

Introduction:Sociodemographic disparities in genitourinary cancer-related mortality have been insufficiently studied, particularly across multiple cancer types. This study aimed to investigate gender, racial, and geographic disparities in mortality rates for the most common genitourinary cancers in the United States.

Methods:Mortality data for prostate, bladder, kidney, and testicular cancers were obtained from the Centers for Disease Control and Prevention (CDC) WONDER database between 1999 and 2020. Age-adjusted mortality rates (AAMRs) were analyzed by year, gender, race, urban-rural status, and geographic region using a significance level of p < 0.05.

Results:Overall, AAMRs for prostate, bladder, and kidney cancer declined significantly, while testicular cancer-related mortality remained stable. Bladder and kidney cancer AAMRs were 3-4 times higher in males than females. Prostate cancer mortality was highest in black individuals/African Americans and began increasing after 2015. Bladder cancer mortality decreased significantly in White individuals, Black individuals, African Americans, and Asians/Pacific Islanders but remained stable in American Indian/Alaska Natives. Kidney cancer-related mortality was highest in White individuals but declined significantly in other races. Testicular cancer mortality increased significantly in White individuals but remained stable in Black individuals and African Americans. Genitourinary cancer mortality decreased in metropolitan areas but either increased (bladder and testicular cancer) or remained stable (kidney cancer) in non-metropolitan areas. Prostate and kidney cancer mortality was highest in the Midwest, bladder cancer in the South, and testicular cancer in the West.

Discussion:Significant sociodemographic disparities exist in the mortality trends of genitourinary cancers in the United States. These findings highlight the need for targeted interventions and further research to address these disparities and improve outcomes for all populations affected by genitourinary cancers.

Document Type

Article

PubMed ID

38966707

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