The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report

Authors

Erin A. Yamamoto, Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239.
Jacob H. Bagley, Advocate Health - MidwestFollow
Mathew Geltzeiler, Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, OR 97239.
Olabisi R. Sanusi, Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239.
Aclan Dogan, Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239.
Jesse J. Liu, Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239.
Juan Piantino, Department of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, OR 97239.

Recommended Citation

Yamamoto EA, Bagley JH, Geltzeiler M, et al. The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report. Proc Natl Acad Sci U S A. 2024;121(42):e2407246121. doi:10.1073/pnas.2407246121

Affiliations

Aurora St. Luke's Medical Center

Abstract

The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.

Document Type

Article

PubMed ID

39374384