Comparison of radial artery compression techniques in contemporary cardiovascular practice: The RAVE trial

Authors

Muddasir Ashraf, Advocate Health - MidwestFollow
Suhail Q. Allaqaband, Advocate Health - MidwestFollow
Louis Kostopoulos, Advocate Health - MidwestFollow
Babak Haddadian, Advocate Health - MidwestFollow
Tanvir Bajwa, Advocate Health - MidwestFollow
Tonga Nfor, Advocate Health - MidwestFollow
Jayant Khitha, Advocate Health - MidwestFollow
Khawaja Afzal Ammar, Advocate Health - MidwestFollow
Ahmad Khraisat, Advocate Health - MidwestFollow
Robert Richmond, Advocate Health - MidwestFollow
Sara Walczak, Advocate Health - MidwestFollow
Wendy Dunaj, Advocate Health - Midwest
Viviana Zlochiver, Advocate Health - MidwestFollow
Kritika Garg, Advocate Health - MidwestFollow
Ana Cristina Perez Moreno, Advocate Health - Midwest
Kirsten Tunink, Advocate Health - Midwest
Theresa Briggs, Advocate Health - MidwestFollow
Jane Meitler, Advocate Health - MidwestFollow
Michelle Bennett, Advocate Health - MidwestFollow
M Fuad Jan, Advocate Health - MidwestFollow

Recommended Citation

Ashraf M, Allaqaband SQ, Kostopoulos L, et al. Comparison of Radial Artery Compression Techniques in Contemporary Cardiovascular Practice: The RAVE Trial. Journal of Interventional Cardiology. 2025;2025(1):1447277. doi:10.1155/joic/1447277

Affiliations

Aurora Sinai/Aurora St. Luke’s Medical Centers

Abstract

Background: The shorter time to hemostasis in patients who undergo transradial cardiac catheterization may reduce the complications, cause less pain, facilitate early discharge, and improve patient satisfaction.

Objective: This trial aimed to evaluate if SoftSeal-STF (Chitogen Inc., Plymouth, MN) with manual compression alone or in combination with a radial compression device (RCD) would reduce time to hemostasis compared to patients with RCD only (Vasc Band).

Methods: We enrolled 300 patients in four arms, including SoftSeal-STF with manual compression, Vasc Band (standard of care), SoftSeal-STF with TR Band, and SoftSeal-STF with EasyClik. This study was analyzed as an observational study due to modification in the design of a randomized trial. The primary outcome was time to hemostasis; the secondary outcomes were complications before discharge, a 3 day follow-up, and a follow-up office visit (30–45 days postprocedure).

Results: The median time to hemostasis (interquartile range [IQR]) was significantly lower in the SoftSeal-STF + TR Band group and the SoftSeal-STF + EasyClik group than in the Vasc Band group (45 [40–69] minutes vs. 120 [120–124] minutes, p < 0.0001; 44 [40–58.5] minutes vs. 120 [120–124] minutes, p < 0.0001, respectively). The median time to hemostasis (IQR) was not different between SoftSeal-STF + TR Band and SoftSeal-STF + EasyClik (45 [40–69] minutes vs. 44 [40–58.5] minutes, p = 0.3). The median time to hemostasis (IQR) was lowest in the SoftSeal-STF + manual compression group (19 [15–30] minutes), but these patients had more postoperative pain and bruising along with logistic issues within the catheterization lab.

Conclusion: The SoftSeal-STF + RCD is a safe and time-efficient strategy in patients who undergo transradial cardiac catheterization. (Radial Artery Vascular Complication and Resource Utilization [RAVE]).

Trial Registration: ClinicalTrials.gov identifier: NCT03522077

Type

Article