Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus

Authors

• Karima Addetia, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States. Electronic address: kaddetia@medicine.bsd.uchicago.edu.
• Michael Henry, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Heather Smith, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Megan Yamat, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Gene Kim, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Renuka Jain, Advocate Health - MidwestFollow
• Eisha Wali, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Linda Lee, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Nathan Marzlin, Advocate Health - Midwest
• AbdulRahman Abutaleb, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Jonathan Crouch, Advocate Health - MidwestFollow
• Eric S. Weiss, Advocate Health - MidwestFollow
• Takeyoshi Ota, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Christopher Salerno, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Huihua Li, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Aliya Husain, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Valluvan Jeevanandam, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.
• Roberto M. Lang, Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.

Recommended Citation

Addetia K, Henry M, Smith H, et al. Mechanisms of Cardiac Implantable Electronic Device Interference With the Tricuspid Valve Apparatus. Am J Cardiol. 2025;250:30-37. doi:10.1016/j.amjcard.2025.04.016

Affiliations

Aurora Sinai/Aurora St. Luke's Medical Centers

Abstract

Cardiac implantable electronic devices (CIEDs) have been implicated in the development of tricuspid valve (TV) dysfunction. However, the mechanisms of dysfunction are not well characterized. We sought to define the prevalence, location and mechanisms of CIED-TV interference based on direct inspection of gross pathologic specimens from consecutive patients with CIEDs who had undergone orthotopic heart transplantation (OHT). CIED-interference was classified by location (septal, posterior or anterior trigone of the RV), portion of TV apparatus involved (leaflet(s) only, sub-tricuspid apparatus (STA) only or a combination of both leaflet and STA) and type of interference (adherence, trapping or both). Sixty-two cases of CIED-TV interference were identified (5 leaflet, 30 STA and 27 leaflet and STA). The majority of patients had non-ischemic cardiomyopathy (81%) and leads in situ for

Type

Article

PubMed ID

40280194