Extensive calcification of the ventricular septum in gene-positive (MYBPC3) nonobstructive hypertrophic cardiomyopathy

Authors

Prabhjot Hundal, Advocate Health - MidwestFollow
Omar Nahhas, Advocate Health - MidwestFollow
M Fuad Jan, Advocate Health - MidwestFollow
A Jamil Tajik, Advocate Health - MidwestFollow
Patrycja Galazka, Advocate Health - MidwestFollow

Recommended Citation

Hundal P, Nahhas O, Jan MF, Tajik AJ, Galazka P. Extensive Calcification of the Ventricular Septum in Gene-Positive (MYBPC3) Nonobstructive Hypertrophic Cardiomyopathy. JACC Case Rep. 2025;30(26):104887. doi:10.1016/j.jaccas.2025.104887

Affiliations

Aurora Sinai/Aurora St Luke's Medical Centers

Abstract

Images: We present multimodality imaging of ventricular septal calcification.

Case summary: A 38-year-old man with asymptomatic gene-positive hypertrophic cardiomyopathy was found to have extensive dystrophic calcification of the ventricular septum. We hypothesized that the extensive ventricular septal calcification would represent an area of severe myocardial fibrosis, resulting in calcification secondary to postsurgical (septal myectomy) changes.

Take-home message: Calcification of the ventricular septum is a rare finding, not previously described following septal myectomy, that should prompt a comprehensive evaluation and follow-up with multimodality imaging and testing.

Type

Article

PubMed ID

40912835