Aortic stenosis progression: Lessons from multimodality imaging

Authors

• Renuka Jain, Advocate Health - MidwestFollow
• Ratnasari Padang, Department of Cardiovascular Medicine,3 Mayo Clinic, Rochester, Minnesota USA.
• Alexander Postalian, The Texas Heart Institute, Houston, Texas USA.
• Jacob P. Dal-Bianco, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts USA.
• Bryan M. Zweig, Heart and Vascular Institute, Department of Medicine, Henry Ford Health, Detroit, Michigan.
• Saki Ito, Department of Cardiovascular Medicine,3 Mayo Clinic, Rochester, Minnesota USA.
• Roberto Hodara, UPMC Heart and Vascular Institute, Harrisburg, PA.
• Robert A. Levine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts USA.
• Jae K. Oh, Department of Cardiovascular Medicine,3 Mayo Clinic, Rochester, Minnesota USA.

Recommended Citation

Jain R, Padang R, Postalian A, et al. Aortic Stenosis Progression: Lessons from Multimodality Imaging. Mayo Clin Proc. Published online June 12, 2026. doi:10.1016/j.mayocp.2026.06.008

Affiliations

Aurora Sinai/Aurora St. Luke's Medical Centers

Abstract

Calcific aortic stenosis primarily affects the aging population and is associated with significant morbidity and mortality. The progression of aortic stenosis from sclerotic aortic valve to severe aortic stenosis is an active metabolic process that involves multiple signaling pathways. Multimodality imaging can assess aortic valve calcification and metabolic activity and quantify severity of disease. This review describes the clinical utility of echocardiography, cardiac magnetic resonance imaging, cardiac computed tomography, and nuclear imaging in the assessment of aortic stenosis. These imaging checkpoints may also serve as targets of clinical research trials aimed at halting the progression of aortic stenosis.

Type

Article

PubMed ID

42285495