The Effects of a Mindfulness-Based Intervention on Depression and Anxiety in the Long-COVID Population

Authors

Rachel Welbel, Rush UniversityFollow
Elizabeth Rutha, Advocate HealthFollow
Jeffrey Ording, Advocate HealthFollow
Douglas Wang, Rosalind Franklin University of Medicine and ScienceFollow
Jana Hirschtick, Advocate HealthFollow

Publication Date

7-15-2025

Keywords

long-COVID, COVID-19, mindfulness, depression, anxiety

Abstract

Long-COVID is a complicated, post-viral syndrome involving multiple body systems and can present with neuropsychiatric symptoms. Little has been reported about the neuropsychiatric symptoms of long-COVID, and validated treatments do not yet exist. There is prior evidence that mindfulnessbased strategies have been helpful for those with chronic illnesses; shown significant decreases in anxiety, stress, and depression; and enhanced quality of life. In this study, we report on the utility of a mindfulness-based intervention on levels of anxiety and depression in a long-COVID population. Our hospital system founded both a “Covid Recovery Clinic” (CRC) and a “Post-COVID Resilience Program” (PCRP). The PCRP consisted of a six-week virtual group therapy protocol that focused on mindfulness-based practices. Before and after the therapy intervention, participants answered questionnaires to capture depressive and anxiety symptoms. Pre- and post-questionnaire scores do not show a significant improvement in depressive or anxiety symptoms, although the study was limited by a small sample size. Further research is needed to investigate whether similar programs with a larger sample size can improve the mental health status of patients suffering from long-COVID.

Recommended Citation

Welbel R, Rutha E, Ording J, et al. The effects of a mindfulness-based intervention on depression and anxiety in the long-COVID population. J Patient Cent Res Rev. 2025;12:134-139. 10.17294/2330-0698.2128