magnetic resonance imaging, endometrioid endometrial cancer, tumor diameter, myometrial invasion
This pilot study aimed to assess the feasibility of precisely measuring tumor diameter and myometrial invasion in patients with endometrioid endometrial cancer (EEC) using preoperative contrast-enhanced magnetic resonance imaging (MRI). Adult patients with confirmed diagnosis of complex hyperplasia with atypia or EEC were included. Three radiologists separately measured tumor diameter and myometrial invasion. Basic descriptive statistics were used to describe patient characteristics and to compare radiology- and pathology-measured tumor diameter and myometrial invasion. Using the pathology results for tumor diameter as the gold standard for comparison, at least 1 radiologist was able to predict largest tumor diameter within 5 mm for 41.7% of patients. Similarly, based on pathology results for myometrial invasion, at least 1 radiologist was able to predict myometrial invasion within 5% for 50% of patients. All radiologists were able to predict superficial (< 50%) or deep (≥ 50%) myometrial invasion for 75% of patients, with greater sensitivity, specificity, and accuracy for deep myometrial invasion. Given variation among radiologic measurements, it is difficult to recommend preoperative MRI as a basis for measuring tumor diameter and myometrial invasion. Even so, the ability to predict superficial versus deep myometrial invasion may benefit patients with EEC for whom surgery is not a viable option or for those seeking fertility-sparing treatment options.
Dickson Michelson EL, Kram JJ, Heslin K, Baugh D, Bamra V, Hu J, Shukla A, Kamelle SA. Can magnetic resonance imaging predict pathologic findings for endometrioid endometrial cancer? J Patient Cent Res Rev. 2020;7:206-12. doi: 10.17294/2330-0698.1720
Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Female Urogenital Diseases and Pregnancy Complications Commons, Neoplasms Commons, Obstetrics and Gynecology Commons, Oncology Commons, Women's Health Commons
July 12th, 2019
September 9th, 2019