Case commentary: Another prong of attack? Topical antibiotic instillation with negative pressure wound therapy for nontuberculous mycobacterial skin and soft tissue infections

Authors

David C. Nguyen, Department of Pediatrics, Division of Pediatric Infectious Diseases, Rush Medical College, Chicago, Illinois, USA.
Angel M. Buettner, Advocate Aurora HealthFollow
Khalid M. Dousa, Department of Medicine, Case Western Reserve University and Medicine Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA.

Recommended Citation

Nguyen DC, Buettner AM, Dousa KM. Case Commentary: Another prong of attack? Topical antibiotic instillation with negative pressure wound therapy for nontuberculous mycobacterial skin and soft tissue infections. Antimicrob Agents Chemother. 2023;67(12):e0104823. doi:10.1128/aac.01048-23

Abstract

Nontuberculous mycobacteria (NTM) skin infections remain therapeutically challenging. Given the diversity in infections, host responses, and antimicrobials, clinical guidelines are often built on case series and observational studies. In this commentary, we respond to a paper by Stemkens et al. that introduces an emerging strategy: adjunctive negative pressure wound therapy with instillation and dwell time combined with topical antibiotics for refractory NTM skin and soft tissue infections. We delve into the primary considerations surrounding this innovative approach.

Document Type

Article

PubMed ID

38014943