Non-human papillomavirus cervical mucinous adenocarcinoma in a phenotypic male with congenital adrenal hyperplasia

Authors

Jennifer Heim
Elizabeth L. Dickson, Advocate Aurora HealthFollow
Melissa Aa Geller
Colleen Rivard

Recommended Citation

Heim J, Dickson E, Geller MA, Rivard C. Non-human Papillomavirus Cervical Mucinous Adenocarcinoma in a Phenotypic Male with Congenital Adrenal Hyperplasia. Cureus. 2018;10(11):e3607. doi: 10.7759/cureus.3607.

Affiliations

Obstetrics and Gynecology, Aurora Health

Abstract

A majority of cervical cancers are caused by human papillomavirus (HPV); however, HPV-negative cervical cancers exist and, though rare, are more aggressive. No prior reports examine HPV-negative cancer of the cervix in a female pseudohermaphrodite with congenital adrenal hyperplasia (CAH). This is a case of a 78-year-old phenotypic male with hypospadias and absent testicles who presented with urinary retention and urosepsis. He was diagnosed with a pelvic mass on imaging and with a female mosaic karyotype (45,X/47,XXX/46 XX). He was taken to the operating room and found to have a rare form of HPV-negative cervical cancer: gastric-type adenocarcinoma (GAS). This study examines the presentation, management, and outcome of a GAS cervical cancer in a patient with a known lack of HPV exposure secondary to the unique anatomy of female pseudohermaphrodism.

Document Type

Article

PubMed ID

30680268