Oseltamivir and baloxavir: dual treatment for rapidly developing ARDS on a patient with renal disease

Authors

Pool Tobar, Advocate Aurora HealthFollow
Elena Caldeira, Advocate Aurora HealthFollow
Hasan Abad, Advocate Aurora HealthFollow
Peguy Saad, Advocate Aurora HealthFollow
Erik LaChance, Advocate Aurora HealthFollow

Recommended Citation

Tobar Vega P, Caldeira E, Abad H, Saad P, Lachance E. Oseltamivir and baloxavir: Dual treatment for rapidly developing ARDS on a patient with renal disease. IDCases. 2020 May 22;21:e00819. doi: 10.1016/j.idcr.2020.e00819. PMID: 32489873; PMCID: PMC7256313

Affiliations

Advocate Illinois Medical Center, Internal Medicine Department

Advocate Illinois Medical Center, Internal Medicine Department

Advocate Illinois Medical Center, Internal Medicine Department

Advocate Illinois Medical Center, Internal Medicine Department

Advocate Illinois Medical Center, Internal Medicine Department

Abstract

Influenza is an annual epidemic disease that in severe cases can lead to the development of ARDS. Current practice recommends the routine use of neuraminidase inhibitors with emerging evidence for the use of endonuclease inhibitors. We present the case of a 22-year-old female with diabetes and IgG4 tubulo-interstitial nephritis that developed rapidly progressive ARDS from influenza infection requiring ventilatory support and extra corporeal oxygenation in which oseltamivir and baloxavir were used in combination. Patient oxygen requirements and imaging improved significantly after treatment initiation, leading to an overall short period of therapy. We present the first case of a patient treated with this combination in the context of chronic kidney disease.

Document Type

Article

PubMed ID

32489873