Recommended Citation
Zubair H, Ashraf M, Allaqaband S, Bajwa TK. Outcomes in Patients With Major Postprocedural Bleeding After Transcatheter Edge-to-Edge Repair of the Mitral Valve. Presented at Scientific Day; May 21, 2025; Park Ridge, IL.
Abstract
Background/Significance:
Real-world outcomes in patients with major post-procedure bleeding after mitral transcatheter edge-to-edge repair (TEER) from a large national database are unknown.
Purpose:
To study major bleeding outcomes in patients undergoing mitral TEER in order to implement and improve bleeding mitigation strategies.
Methods:
We used the National Inpatient Sample from 2013 to 2020 in our study. ICD-9 and ICD-10 codes were used to identify our study population. Linear and logistic regression were used to obtain unadjusted and adjusted estimates. Major bleeding was defined by any bleeding requiring blood transfusion after TEER.
Results:
Of 43,920 patients with mean age (SE) of 77 (0.13) years, 46% were females. Of these, 2156 (4.9%), had major bleeding requiring blood transfusion. Bleeding rates decreased significantly (P-trend < 0.001) from 21% in 2013 to 4% in 2020. Major bleeding was associated with increased in-hospital mortality on both unadjusted (OR 6.3, P < 0.001) and risk-adjusted (AOR 4.12, P < 0.001) analyses. It was also independently associated with an increased length of stay and cost on both unadjusted and risk adjusted analysis.
Conclusion:
Major bleeding is associated with worse outcomes in patients undergoing mitral TEER. Decreasing trends in these bleeding rates over time shown in our study are encouraging and continued efforts to reduce bleeding rates are needed to further improve these outcomes.
Presentation Notes
Presented at Scientific Day; May 21, 2025; Park Ridge, IL.
Full Text of Presentation
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Document Type
Poster
Outcomes in Patients With Major Postprocedural Bleeding After Transcatheter Edge-to-Edge Repair of the Mitral Valve
Background/Significance:
Real-world outcomes in patients with major post-procedure bleeding after mitral transcatheter edge-to-edge repair (TEER) from a large national database are unknown.
Purpose:
To study major bleeding outcomes in patients undergoing mitral TEER in order to implement and improve bleeding mitigation strategies.
Methods:
We used the National Inpatient Sample from 2013 to 2020 in our study. ICD-9 and ICD-10 codes were used to identify our study population. Linear and logistic regression were used to obtain unadjusted and adjusted estimates. Major bleeding was defined by any bleeding requiring blood transfusion after TEER.
Results:
Of 43,920 patients with mean age (SE) of 77 (0.13) years, 46% were females. Of these, 2156 (4.9%), had major bleeding requiring blood transfusion. Bleeding rates decreased significantly (P-trend < 0.001) from 21% in 2013 to 4% in 2020. Major bleeding was associated with increased in-hospital mortality on both unadjusted (OR 6.3, P < 0.001) and risk-adjusted (AOR 4.12, P < 0.001) analyses. It was also independently associated with an increased length of stay and cost on both unadjusted and risk adjusted analysis.
Conclusion:
Major bleeding is associated with worse outcomes in patients undergoing mitral TEER. Decreasing trends in these bleeding rates over time shown in our study are encouraging and continued efforts to reduce bleeding rates are needed to further improve these outcomes.
Affiliations
Aurora St. Luke's Medical Center