60. Impact of hepatic disease
Recommended Citation
Zubair MH, De Ranieri A. Impact of hepatic disease. In: Abd-Elsayed A, Abd-Elsayed A, eds. Basic Anesthesia Review. Oxford University Press; 2024:160-161.
Abstract
The liver is the predominant site of metabolism for nearly all drugs absorbed from the gastrointestinal tract, and the role of hepatic system is not limited to glucose metabolism, protein synthesis, and functioning as a blood reservoir, but also functions to metabolically transform various drugs into either active and inactive forms. The hepatic system is connected to the heart via the hepatic arteries, which draws two-third of the blood from the spleen, pancreas, and stomach. Phase I and phase II reactions govern most drug metabolism. The substrates of the cytochrome enzyme system, along with their inducers and inhibitors, can aid in anesthetic management of patients with liver disease. Thus an understanding of hepatic physiology and pathology is critical to the anesthetic management of the patient.
Type
Book Chapter
Book Chapter/Book Details
In: Abd-Elsayed A, Abd-Elsayed A, eds. Basic Anesthesia Review. Oxford University Press; 2024.