63. Drug-drug binding
Recommended Citation
Ozinga J, Knezevic NN. Drug-Drug Binding. In: Abd-Elsayed A, Abd-Elsayed A, eds. Basic Anesthesia Review. Oxford University Press; 2024:167-169.
Abstract
This chapter discusses the main concept of drug-drug binding, defining the key elements of drug-drug interaction such as affinity, potency, different types of dose-response curves, etc. Knowledge of whether the drug is a full or partial agonist, and whether antagonism is competitive or noncompetitive is requisite prior to drug administration. Furthermore, the pharmacodynamic profile of a drug is an important variable when evaluating concentration-dependent effects of that drug. Being aware of pharmacodynamic drug-drug interactions, based on drug-drug binding and different types of synergism and antagonism, is an essential part of anesthesia practice.
Type
Book Chapter
Book Chapter/Book Details
In: Abd-Elsayed A, Abd-Elsayed A, eds. Basic Anesthesia Review. Oxford University Press; 2024.